About

MedLytic Labs score technology provides faster, more accurate and reliable techniques for diagnosis (calculating Fractional Flow Reserve (FFR) index) and treating (with robust stent deployment) Coronary Artery Disease (CAD). We believe that our FFR2D product will be a paradigm shift and will set new standards in interventional cardiology, and it will become indispensable in the more than 6,000 interventional cath labs worldwide. At the core of our technology is both mathematical and numerical modelling. In the former mathematical formulas are used to compute pressure drop along the coronary arteries, while in the latter Computational fluid Dynamics (CFD) tools are used to compute pressure drop. Our innovative applications of mathematical modelling to simulate hypeaemia and of CFD to diagnose cardiovascular disease differentiate MedLytic Labs from existing technologies. MedLYTIC Labs will revolutionize treatment decisions for coronary artery disease (CAD). Our software provides a quick, non-invasive and wire-free calculation of Fraction Flow Reserve (FFR). We transform routine angiograms into objective vessel physiologic, along with anatomic insights, providing all information need to optimize percutaneous coronary intervention (PCI) treatment decisions. medLYTIC Labs software aims to eventually replace wire-based FFR measurement and increase physiological coronary lesion assessment.

Solution & Product

X-ray angiography: We use X-ray a single angiographic image to evaluate the physiologic significance of coronary artery stenoses. We numerically compute the Fractional Flow Reserve (FFR) index, without hyperemic stimulus (administering adenosine). How it works: Using a single 2D angiographic image, we apply an image analysis to segment the interrogated vessel. After vessel delineation, we compute geometrical data of the interrogated vessel such as vessel length, minimum lumen area (MLA), length of the stenosis, vessel volume, mean volumetric flow rate, coronary flow ratio (CFR) and using: •tthe geometrical data we compute the FFR flow reserve using well-established equations for pressure drop along the stenosis •tthe TIMI Frame Count (TFC) and the estimated (using only the geometrical data of the vessel) coronary flow ratio (CFR) we compute the Fractional Flow Reserve. Coronary Computed Tomography Angiography (CCTA): We use the 3D reconstructed geometry of the interrogated vessel and we use only geometrical data to compute FFR. How it works: From the 3D geometry (often given as a STL file) of the interrogated vessel, we compute geometrical data such as the centerline, the volume, the length of the stenosis, minimum lumen area (MLA) and coronary flow ratio (CFR). We compute the FFR along the vessel using predefined volumetric flow rates (of 1mL/s and 3 mL/s) and simulating hyperemic flow conditions through a sophisticated mathematical and physiological model.

Innovation & Scalability

There is no other company in the world doing what we do - working with angiographic, CT and MRI data. We are passionate about transforming the diagnosis and management of coronary artery disease and continue to innovate.

Traction & achievements

Algorithm standardization Pilot clinical study with 88 cases for angio FFR Patent Proof of concept for CT-FFR Proof of concept for FFR in peripheral vessels

Team & Why Us

Konstantinos is an Associate Professor of Vascular and Interventional Radiology with nearly 20 years of experience in the imaging and treatment of cardiovascular diseases at Guy’s and St. Thomas’ Hospitals, NHS, London and Patras University hospital, Rion, Greece. He previously held honorary academic tenure at King’s College London, he has already authored or co-authored more than 140 papers in international journals, and is a current member of the EMA Circulatory Panel for approval of medical devices and in vitro diagnostics. Fivos has worked for 7 years as a Lecturer in Finance at the Athens University of Economics and Business and the University of Bern. He then founded NRG Metrics, an ESG- Environmental Social and Governance Data Provider. He has studied Business Administration at the Athens University of Economics. He also holds a MSc in Finance from Bristol University and a PhD in Corporate Finance from Athens University of Economics and Business. George is an Assistant Professor at the University of Patras and Adjunct Lecturer at the Mechanical Engineering Department at the University of Western Australia in Perth. He holds a degree in Physics, MSc in Medial Physics and a PhD in Fluid Mechanics. He has a deep understanding of Numerical Fluid Mechanics & Computational Fluid Dynamics At the heart of our mission is a commitment to making cardiovascular care easier for medical doctors and safer for patients. Physicians get the crucial information they need without added

Funding Needs

Patent Applications EU, USA, UK, Australia, Japan, etc. Regulatory Approvals 510k application in the US FDA, Consulting company, Clinical studies (1 for CA, 1 for CTCA), Quality Management System, Notified Body submission for EU approval (MDR process) Software Development Graphic User Interface, Cloud-based, secured with a direct VPN from PACS to cloud to maintain the highest level of encryption and security, Neural networks and artificial intelligence for fully automated on-the-fly analysis, Administrative Expenses Commercialization